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Screening and identification of small molecule inhibitors of ErbB2‐induced invasion

ERBB2 amplification and overexpression are strongly associated with invasive cancer with high recurrence and poor prognosis. Enhanced ErbB2 signaling induces cysteine cathepsin B and L expression leading to their higher proteolytic activity (zFRase activity), which is crucial for the invasion of Erb...

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Detalhes bibliográficos
Publicado no:Mol Oncol
Main Authors: Brix, D.M., Rafn, B., Bundgaard Clemmensen, K., Andersen, S.H., Ambartsumian, N., Jäättelä, M., Kallunki, T.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528609/
https://ncbi.nlm.nih.gov/pubmed/25070180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2014.07.004
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