Inhibition of PARP1‐dependent end‐joining contributes to Olaparib‐mediated radiosensitization in tumor cells

Poly‐ADP‐ribose‐polymerase inhibitors (PARPi) are considered to be optimal tools for specifically enhancing radiosensitivity. This effect has been shown to be replication‐dependent and more profound in HR‐deficient tumors. Here, we present a new mode of PARPi‐mediated radiosensitization which was ob...

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Bibliografiske detaljer
Udgivet i:Mol Oncol
Main Authors: Kötter, Annika, Cornils, Kerstin, Borgmann, Kerstin, Dahm-Daphi, Jochen, Petersen, Cordula, Dikomey, Ekkehard, Mansour, Wael Y.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2014
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528607/
https://ncbi.nlm.nih.gov/pubmed/25028150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2014.06.008
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