BRCA2 inhibition enhances cisplatin‐mediated alterations in tumor cell proliferation, metabolism, and metastasis

Tumor cells have unstable genomes relative to non‐tumor cells. Decreased DNA integrity resulting from tumor cell instability is important in generating favorable therapeutic indices, and intact DNA repair mediates resistance to therapy. Targeting DNA repair to promote the action of anti‐cancer agent...

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Detalhes bibliográficos
Publicado no:Mol Oncol
Main Authors: Rytelewski, Mateusz, Tong, Jessica G., Buensuceso, Adrian, Leong, Hon S., Maleki Vareki, Saman, Figueredo, Rene, Di Cresce, Christine, Wu, Sherry Y., Herbrich, Shelley M., Baggerly, Keith A., Romanow, Larissa, Shepherd, Trevor, Deroo, Bonnie J., Sood, Anil K., Chambers, Ann F., Vincent, Mark, Ferguson, Peter J., Koropatnick, James
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2014
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528603/
https://ncbi.nlm.nih.gov/pubmed/24974076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2014.05.017
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