siRNA knockdown of mitochondrial thymidine kinase 2 (TK2) sensitizes human tumor cells to gemcitabine

Nucleoside metabolism enzymes are determinants of chemotherapeutic drug activity. The nucleoside salvage enzyme deoxycytidine kinase (dCK) activates gemcitabine (2′, 2′-difluoro-2′-deoxycytidine) and is negatively regulated by deoxycytidine triphosphate (dCTP). Reduction of dCTP in tumor cells could...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Di Cresce, Christine, Figueredo, Rene, Rytelewski, Mateusz, Vareki, Saman Maleki, Way, Colin, Ferguson, Peter J., Vincent, Mark D., Koropatnick, James
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673171/
https://ncbi.nlm.nih.gov/pubmed/26087398
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