Whole genome RNAi screens reveal a critical role of REV3 in coping with replication stress

REV3, the catalytic subunit of translesion polymerase zeta (polζ), is commonly associated with DNA damage bypass and repair. Despite sharing accessory subunits with replicative polymerase δ, very little is known about the role of polζ in DNA replication. We previously demonstrated that inhibition of...

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Detalhes bibliográficos
Publicado no:Mol Oncol
Main Authors: Kotov, Ilya N., Siebring-van Olst, Ellen, Knobel, Philip A., van der Meulen-Muileman, Ida H., Felley-Bosco, Emanuela, van Beusechem, Victor W., Smit, Egbert F., Stahel, Rolf A., Marti, Thomas M.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2014
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528584/
https://ncbi.nlm.nih.gov/pubmed/25113059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2014.07.008
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