Whole genome RNAi screens reveal a critical role of REV3 in coping with replication stress

REV3, the catalytic subunit of translesion polymerase zeta (polζ), is commonly associated with DNA damage bypass and repair. Despite sharing accessory subunits with replicative polymerase δ, very little is known about the role of polζ in DNA replication. We previously demonstrated that inhibition of...

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Vydáno v:Mol Oncol
Hlavní autoři: Kotov, Ilya N., Siebring-van Olst, Ellen, Knobel, Philip A., van der Meulen-Muileman, Ida H., Felley-Bosco, Emanuela, van Beusechem, Victor W., Smit, Egbert F., Stahel, Rolf A., Marti, Thomas M.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2014
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528584/
https://ncbi.nlm.nih.gov/pubmed/25113059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2014.07.008
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