Whole genome RNAi screens reveal a critical role of REV3 in coping with replication stress

REV3, the catalytic subunit of translesion polymerase zeta (polζ), is commonly associated with DNA damage bypass and repair. Despite sharing accessory subunits with replicative polymerase δ, very little is known about the role of polζ in DNA replication. We previously demonstrated that inhibition of...

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Bibliographic Details
Published in:Mol Oncol
Main Authors: Kotov, Ilya N., Siebring-van Olst, Ellen, Knobel, Philip A., van der Meulen-Muileman, Ida H., Felley-Bosco, Emanuela, van Beusechem, Victor W., Smit, Egbert F., Stahel, Rolf A., Marti, Thomas M.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2014
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528584/
https://ncbi.nlm.nih.gov/pubmed/25113059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2014.07.008
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