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Pharmacologic inhibition of vacuolar H+ ATPase reduces physiologic and oncogenic Notch signaling

Notch signaling in prominently involved in growth regulation in metazoan tissues. Because of this, Notch is often upregulated in cancer and current efforts point to developing drugs that block its activation. Notch receptor endocytosis towards acidic compartments is a recently appreciated determinan...

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Publicado en:Mol Oncol
Main Authors: Kobia, Francis, Duchi, Serena, Deflorian, Gianluca, Vaccari, Thomas
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528540/
https://ncbi.nlm.nih.gov/pubmed/24309677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2013.11.002
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