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V‐ATPase inhibition overcomes trastuzumab resistance in breast cancer

The HER2 oncogene targeting drug trastuzumab shows remarkable efficacy in patients overexpressing HER2. However acquired or primary resistance develops in most of the treated patients why alternative treatment strategies are strongly needed. As endosomal sorting and recycling are crucial steps for H...

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Detalhes bibliográficos
Publicado no:Mol Oncol
Main Authors: von Schwarzenberg, Karin, Lajtos, Tamás, Simon, Làszló, Müller, Rolf, Vereb, György, Vollmar, Angelika M.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528506/
https://ncbi.nlm.nih.gov/pubmed/24055142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2013.08.011
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