V-ATPase inhibition increases cancer cell stiffness and blocks membrane related Ras signaling - a new option for HCC therapy

Hepatocellular carcinoma (HCC) is the fifth most frequent cancer worldwide and the third leading cause of cancer-related death. However, therapy options are limited leaving an urgent need to develop new strategies. Currently, targeting cancer cell lipid and cholesterol metabolism is gaining interest...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Bartel, Karin, Winzi, Maria, Ulrich, Melanie, Koeberle, Andreas, Menche, Dirk, Werz, Oliver, Müller, Rolf, Guck, Jochen, Vollmar, Angelika M., von Schwarzenberg, Karin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354746/
https://ncbi.nlm.nih.gov/pubmed/28036299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14339
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