The design and optimization of RNA trans‐splicing molecules for skin cancer therapy

Targeting tumor marker genes by RNA trans‐splicing is a promising means to induce tumor cell‐specific death. Using a screening system we designed RNA trans‐splicing molecules (RTM) specifically binding the pre‐mRNA of SLCO1B3, a marker gene in epidermolysis bullosa associated squamous cell carcinoma...

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Bibliographic Details
Published in:Mol Oncol
Main Authors: Gruber, Christina, Koller, Ulrich, Murauer, Eva M., Hainzl, Stefan, Hüttner, Clemens, Kocher, Thomas, South, Andrew P., Hintner, Helmut, Bauer, Johann W.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2013
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528447/
https://ncbi.nlm.nih.gov/pubmed/23998959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2013.08.005
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