Epithelial‐mesenchymal transition leads to crizotinib resistance in H2228 lung cancer cells with EML4‐ALK translocation

Epithelial‐mesenchymal transition (EMT) is associated with reduced sensitivity to many chemotherapeutic drugs, including EGFR tyrosine kinase inhibitors. Here, we investigated if this reduced sensitivity also contributes to resistance to crizotinib, an ALK inhibitor of lung cancer that exhibits the...

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Bibliographische Detailangaben
Veröffentlicht in:Mol Oncol
Hauptverfasser: Kim, Hyeong Ryul, Kim, Woo Sung, Choi, Yun Jung, Choi, Chang Min, Rho, Jin Kyung, Lee, Jae Cheol
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2013
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528442/
https://ncbi.nlm.nih.gov/pubmed/23993685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2013.08.001
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