Crizotinib-Resistant Mutants of EML4-ALK Identified Through an Accelerated Mutagenesis Screen

Activating gene rearrangements of anaplastic lymphoma kinase (ALK) have been identified as driver mutations in non-small-cell lung cancer, inflammatory myofibroblastic tumors, and other cancers. Crizotinib, a dual MET/ALK inhibitor, has demonstrated promising clinical activity in patients with non-s...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Zhang, Sen, Wang, Frank, Keats, Jeffrey, Zhu, Xiaotian, Ning, Yaoyu, Wardwell, Scott D, Moran, Lauren, Mohemmad, Qurish K, Anjum, Rana, Wang, Yihan, Narasimhan, Narayana I, Dalgarno, David, Shakespeare, William C, Miret, Juan J, Clackson, Tim, Rivera, Victor M
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Ltd 2011
Fag:
Research Letters
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265718/
https://ncbi.nlm.nih.gov/pubmed/22034911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1747-0285.2011.01239.x
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker