Isolated central nervous system progression on Crizotinib: An Achilles heel of non-small cell lung cancer with EML4-ALK translocation?

Advanced non-small lung cancer (NSCLC) remains almost uniformly lethal with marginal long-term survival despite efforts to target specific oncogenic addiction pathways that may drive these tumors with small molecularly targeted agents and biologics. The EML4-ALK fusion gene encodes a chimeric tyrosi...

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Hlavní autoři: Chun, Stephen G., Choe, Kevin S., Iyengar, Puneeth, Yordy, John S., Timmerman, Robert D.
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2012
Témata:
Bedside to Bench Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3542227/
https://ncbi.nlm.nih.gov/pubmed/22986231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.22255
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