Reversal of gastrointestinal carcinoma‐induced immunosuppression and induction of antitumoural immunity by a combination of cyclophosphamide and gene transfer of IL‐12

Immunotherapy‐based strategies for gastrointestinal carcinomas (GIC) have been exploited so far, but these approaches have to face strong mechanisms of immune escape induced by tumours. We previously demonstrated that sub‐therapeutic doses of an adenovirus expressing IL‐12 genes (AdIL‐12) mediated a...

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Publicado en:Mol Oncol
Autores principales: Malvicini, Mariana, Ingolotti, Mariana, Piccioni, Flavia, Garcia, Mariana, Bayo, Juan, Atorrasagasti, Catalina, Alaniz, Laura, Aquino, Jorge B., Espinoza, Jaime A., Gidekel, Manuel, Scharovsky, O. Graciela, Matar, Pablo, Mazzolini, Guillermo
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2011
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Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528288/
https://ncbi.nlm.nih.gov/pubmed/21515097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2011.03.007
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