Synergistic induction of apoptosis by the Bcl‐2 inhibitor ABT‐737 and imatinib mesylate in gastrointestinal stromal tumor cells

Background: Although imatinib mesylate has revolutionized the management of patients with gastrointestinal stromal tumor (GIST), resistance and progression almost inevitably develop with long‐term monotherapy. To enhance imatinib‐induced cytotoxicity and overcome imatinib‐resistance in GIST cells, w...

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Vydáno v:Mol Oncol
Hlavní autoři: Reynoso, David, Nolden, Laura K., Yang, Dan, Dumont, Sarah N., Conley, Anthony P., Dumont, Amaury G.P., Zhou, Kim, Duensing, Anette, Trent, Jonathan C.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2010
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Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528266/
https://ncbi.nlm.nih.gov/pubmed/21115411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2010.10.003
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