Synergistic induction of apoptosis by the Bcl‐2 inhibitor ABT‐737 and imatinib mesylate in gastrointestinal stromal tumor cells

Background: Although imatinib mesylate has revolutionized the management of patients with gastrointestinal stromal tumor (GIST), resistance and progression almost inevitably develop with long‐term monotherapy. To enhance imatinib‐induced cytotoxicity and overcome imatinib‐resistance in GIST cells, w...

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Detalhes bibliográficos
Publicado no:Mol Oncol
Main Authors: Reynoso, David, Nolden, Laura K., Yang, Dan, Dumont, Sarah N., Conley, Anthony P., Dumont, Amaury G.P., Zhou, Kim, Duensing, Anette, Trent, Jonathan C.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2010
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528266/
https://ncbi.nlm.nih.gov/pubmed/21115411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2010.10.003
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