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Privileged electrophile sensors: a resource for covalent drug development
This Perspective delineates how redox signaling impacts activity of specific enzyme isoforms and how this property may be harnessed for rational drug design. Covalent drugs have resurged in recent years and several reports have extolled the general virtues of developing irreversible inhibitors. Inde...
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| Pubblicato in: | Cell Chem Biol |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5528179/ https://ncbi.nlm.nih.gov/pubmed/28648380 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2017.05.023 |
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