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Particulate array of well-ordered HIV clade C Env trimers elicits neutralizing antibodies that display a unique V2 cap approach
The development of soluble envelope glycoprotein (Env) mimetics displaying ordered trimeric symmetry has ushered in a new era in HIV-1 vaccination. The recently reported native, flexibly linked (NFL) design allows the generation of native-like trimers from clinical isolates at high yields and homoge...
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發表在: | Immunity |
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Main Authors: | , , , , , , , , , , , , , , , , , , |
格式: | Artigo |
語言: | Inglês |
出版: |
2017
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主題: | |
在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5528178/ https://ncbi.nlm.nih.gov/pubmed/28514687 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2017.04.021 |
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