MORC-1 integrates nuclear RNAi and transgenerational chromatin architecture to promote germline immortality

Germline-expressed endogenous siRNAs (endo-siRNAs) transmit multigenerational epigenetic information to ensure fertility in subsequent generations. In C. elegans, nuclear RNAi ensures robust inheritance of endo-siRNAs and deposition of repressive H3K9me3 marks at target loci. How target silencing is...

詳細記述

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書誌詳細
出版年:Dev Cell
主要な著者: Weiser, Natasha E., Yang, Danny X., Feng, Suhua, Kalinava, Natallia, Brown, Kristen C., Khanikar, Jayshree, Freeberg, Mallory A., Snyder, Martha J., Csankovszki, Gyorgyi, Chan, Raymond C., Gu, Sam G., Montgomery, Taiowa A., Jacobsen, Steven E., Kim, John K.
フォーマット: Artigo
言語:Inglês
出版事項: 2017
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527976/
https://ncbi.nlm.nih.gov/pubmed/28535375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2017.04.023
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