Decoupling the downstream effects of germline nuclear RNAi reveals that H3K9me3 is dispensable for heritable RNAi and the maintenance of endogenous siRNA-mediated transcriptional silencing in Caenorhabditis elegans

BACKGROUND: Germline nuclear RNAi in C. elegans is a transgenerational gene-silencing pathway that leads to H3K9 trimethylation (H3K9me3) and transcriptional silencing at the target genes. H3K9me3 induced by either exogenous double-stranded RNA (dsRNA) or endogenous siRNA (endo-siRNA) is highly spec...

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Detalhes bibliográficos
Publicado no:Epigenetics Chromatin
Main Authors: Kalinava, Natallia, Ni, Julie Zhouli, Peterman, Kimberly, Chen, Esteban, Gu, Sam Guoping
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
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Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5311726/
https://ncbi.nlm.nih.gov/pubmed/28228846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13072-017-0114-8
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