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3‐Bromopyruvate as inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs
Tumour cells depend on aerobic glycolysis for adenosine triphosphate (ATP) production, making energy metabolism an interesting therapeutic target. 3‐Bromopyruvate (BP) has been shown by others to inhibit hexokinase and eradicate mouse hepatocarcinomas. We report that similar to the glycolysis inhibi...
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| Publicado no: | Mol Oncol |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5527790/ https://ncbi.nlm.nih.gov/pubmed/19383331 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2008.01.003 |
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