Safety, Tolerability, Systemic Exposure, and Metabolism of CRS3123, a Methionyl-tRNA Synthetase Inhibitor Developed for Treatment of Clostridium difficile, in a Phase 1 Study

Clostridium difficile causes antibiotic-associated diarrhea and is a major public health concern. Current therapies disrupt the protective intestinal flora, do not reliably prevent recurrent infections, and will be decreasingly effective should less susceptible strains emerge. CRS3123 is an oral age...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Nayak, Seema U., Griffiss, J. McLeod, Blumer, Jeffrey, O'Riordan, Mary Ann, Gray, Wesley, McKenzie, Robin, Jurao, Robert A., An, Amanda T., Le, Melissa, Bell, Stacie J., Ochsner, Urs A., Jarvis, Thale C., Janjic, Nebojsa, Zenilman, Jonathan M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527627/
https://ncbi.nlm.nih.gov/pubmed/28584140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02760-16
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