Multimechanistic Monoclonal Antibodies (MAbs) Targeting Staphylococcus aureus Alpha-Toxin and Clumping Factor A: Activity and Efficacy Comparisons of a MAb Combination and an Engineered Bispecific Antibody Approach

Secreted alpha-toxin and surface-localized clumping factor A (ClfA) are key virulence determinants in Staphylococcus aureus bloodstream infections. We previously demonstrated that prophylaxis with a multimechanistic monoclonal antibody (MAb) combination against alpha-toxin (MEDI4893*) and ClfA (11H1...

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Détails bibliographiques
Publié dans:Antimicrob Agents Chemother
Auteurs principaux: Tkaczyk, C., Kasturirangan, S., Minola, A., Jones-Nelson, O., Gunter, V., Shi, Y. Y., Rosenthal, K., Aleti, V., Semenova, E., Warrener, P., Tabor, D., Stover, C. K., Corti, D., Rainey, G., Sellman, B. R.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2017
Sujets:
Experimental Therapeutics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527613/
https://ncbi.nlm.nih.gov/pubmed/28584141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00629-17
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