Alanine Scanning Mutagenesis of the MEDI4893 (Suvratoxumab) Epitope Reduces Alpha Toxin Lytic Activity In Vitro and Staphylococcus aureus Fitness in Infection Models

Alpha toxin (AT) is a cytolytic pore-forming toxin that plays a key role in Staphylococcus aureus pathogenesis; consequently, extensive research was undertaken to understand the AT mechanism of action and its utility as a target for novel prophylaxis and treatment strategies against S. aureus infect...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Tkaczyk, C., Semenova, E., Shi, Y. Y., Rosenthal, K., Oganesyan, V., Warrener, P., Stover, C. K., Sellman, B. R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Clinical Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6201083/
https://ncbi.nlm.nih.gov/pubmed/30150481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01033-18
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