NMR metabolomics highlights sphingosine kinase‐1 as a new molecular switch in the orchestration of aberrant metabolic phenotype in cancer cells

Strong experimental evidence in animal and cellular models supports a pivotal role of sphingosine kinase‐1 (SK1) in oncogenesis. In many human cancers, SK1 levels are upregulated and these increases are linked to poor prognosis in patients. Here, by employing untargeted NMR‐based metabolomic profili...

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Publicat a:Mol Oncol
Autors principals: Bernacchioni, Caterina, Ghini, Veronica, Cencetti, Francesca, Japtok, Lukasz, Donati, Chiara, Bruni, Paola, Turano, Paola
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2017
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527469/
https://ncbi.nlm.nih.gov/pubmed/28258651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12048
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