NMR metabolomics highlights sphingosine kinase‐1 as a new molecular switch in the orchestration of aberrant metabolic phenotype in cancer cells

Strong experimental evidence in animal and cellular models supports a pivotal role of sphingosine kinase‐1 (SK1) in oncogenesis. In many human cancers, SK1 levels are upregulated and these increases are linked to poor prognosis in patients. Here, by employing untargeted NMR‐based metabolomic profili...

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Detalhes bibliográficos
Publicado no:Mol Oncol
Main Authors: Bernacchioni, Caterina, Ghini, Veronica, Cencetti, Francesca, Japtok, Lukasz, Donati, Chiara, Bruni, Paola, Turano, Paola
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527469/
https://ncbi.nlm.nih.gov/pubmed/28258651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12048
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