A genome‐wide siRNA screen for regulators of tumor suppressor p53 activity in human non‐small cell lung cancer cells identifies components of the RNA splicing machinery as targets for anticancer treatment

Reinstating wild‐type tumor suppressor p53 activity could be a valuable option for the treatment of cancer. To contribute to development of new treatment options for non‐small cell lung cancer (NSCLC), we performed genome‐wide siRNA screens for determinants of p53 activity in NSCLC cells. We identif...

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Publicat a:Mol Oncol
Autors principals: Siebring‐van Olst, Ellen, Blijlevens, Maxime, de Menezes, Renee X., van der Meulen‐Muileman, Ida H., Smit, Egbert F., van Beusechem, Victor W.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2017
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527466/
https://ncbi.nlm.nih.gov/pubmed/28296343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12052
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