Inhibitors of STAT3, β‐catenin, and IGF‐1R sensitize mouse PIK3CA‐mutant breast cancer to PI3K inhibitors

Although mutations in the phosphoinositide 3‐kinase catalytic subunit (PIK3CA) are common in breast cancer, PI3K inhibitors alone have shown modest efficacy. We sought to identify additional pathways altered in PIK3CA‐mutant tumors that might be targeted in combination with PI3K inhibitors. We gener...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Mol Oncol
Main Authors: Merino, Vanessa F., Cho, Soonweng, Liang, Xiaohui, Park, Sunju, Jin, Kideok, Chen, Qian, Pan, Duojia, Zahnow, Cynthia A., Rein, Alan R., Sukumar, Saraswati
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527464/
https://ncbi.nlm.nih.gov/pubmed/28296140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12053
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados