Dysregulation of the miR‐194–CUL4B negative feedback loop drives tumorigenesis in non‐small‐cell lung carcinoma

Cullin 4B (CUL4B), a scaffold protein that assembles CRL4B ubiquitin ligase complexes, is overexpressed in many types of cancers and represses many tumor suppressors through epigenetic mechanisms. However, the mechanisms by which CUL4B is upregulated remain to be elucidated. Here, we show that CUL4B...

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Detalhes bibliográficos
Publicado no:Mol Oncol
Principais autores: Mi, Jun, Zou, Yongxin, Lin, Xiaohua, Lu, Juanjuan, liu, Xiaochen, Zhao, Hui, Ye, Xiang, Hu, Huili, Jiang, Baichun, Han, Bo, Shao, Changshun, Gong, Yaoqin
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527444/
https://ncbi.nlm.nih.gov/pubmed/28164432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12038
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