Dysregulation of the miR‐194–CUL4B negative feedback loop drives tumorigenesis in non‐small‐cell lung carcinoma

Cullin 4B (CUL4B), a scaffold protein that assembles CRL4B ubiquitin ligase complexes, is overexpressed in many types of cancers and represses many tumor suppressors through epigenetic mechanisms. However, the mechanisms by which CUL4B is upregulated remain to be elucidated. Here, we show that CUL4B...

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Bibliografiska uppgifter
I publikationen:Mol Oncol
Huvudupphovsmän: Mi, Jun, Zou, Yongxin, Lin, Xiaohua, Lu, Juanjuan, liu, Xiaochen, Zhao, Hui, Ye, Xiang, Hu, Huili, Jiang, Baichun, Han, Bo, Shao, Changshun, Gong, Yaoqin
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2017
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527444/
https://ncbi.nlm.nih.gov/pubmed/28164432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12038
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