Dysregulation of the miR‐194–CUL4B negative feedback loop drives tumorigenesis in non‐small‐cell lung carcinoma

Cullin 4B (CUL4B), a scaffold protein that assembles CRL4B ubiquitin ligase complexes, is overexpressed in many types of cancers and represses many tumor suppressors through epigenetic mechanisms. However, the mechanisms by which CUL4B is upregulated remain to be elucidated. Here, we show that CUL4B...

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Enregistré dans:
Détails bibliographiques
Publié dans:Mol Oncol
Auteurs principaux: Mi, Jun, Zou, Yongxin, Lin, Xiaohua, Lu, Juanjuan, liu, Xiaochen, Zhao, Hui, Ye, Xiang, Hu, Huili, Jiang, Baichun, Han, Bo, Shao, Changshun, Gong, Yaoqin
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2017
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527444/
https://ncbi.nlm.nih.gov/pubmed/28164432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12038
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