Human proT-cells generated in vitro facilitate hematopoietic stem cell-derived T-lymphopoiesis in vivo and restore thymic architecture

Hematopoietic stem cell transplantation (HSCT) is followed by a period of immune deficiency due to a paucity in T-cell reconstitution. Underlying causes are a severely dysfunctional thymus and an impaired production of thymus-seeding progenitors in the host. Here, we addressed whether in vitro–deriv...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Awong, Génève, Singh, Jastaranpreet, Mohtashami, Mahmood, Malm, Maria, La Motte-Mohs, Ross N., Benveniste, Patricia M., Serra, Pablo, Herer, Elaine, van den Brink, Marcel R., Zúñiga-Pflücker, Juan Carlos
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527400/
https://ncbi.nlm.nih.gov/pubmed/24215033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-12-472803
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