A human thymic epithelial cell culture system for the promotion of lymphopoiesis from hematopoietic stem cells

OBJECTIVE: A human thymic epithelial cell (TEC) line expressing human leukocyte antigen (HLA)-ABC and HLA-DR was engineered to overexpress murine Delta-like 1 (TEC-Dl1) for the purpose of establishing a human culture system that supports T lymphopoiesis from hematopoietic progenitor cells (HPCs). MA...

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Main Authors: Beaudette-Zlatanova, Britte C., Knight, Katherine L., Zhang, Shubin, Stiff, Patrick J., Zúñiga-Pflücker, Juan Carlos, Le, Phong T.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3402177/
https://ncbi.nlm.nih.gov/pubmed/21296124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2011.01.014
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