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Cross-validation of optimized composites for preclinical Alzheimer's disease
INTRODUCTION: We discuss optimization and validation of composite end points for presymptomatic Alzheimer's disease clinical trials. Optimized composites offer hope of substantial gains in statistical power or reduction in sample size. But there is tradeoff between optimization and face validit...
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| Pubblicato in: | Alzheimers Dement (N Y) |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Elsevier
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5527287/ https://ncbi.nlm.nih.gov/pubmed/28758145 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.trci.2016.12.001 |
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