Expression of RMRP RNA is regulated in chondrocyte hypertrophy and determines chondrogenic differentiation

Mutations in the RMRP-gene, encoding the lncRNA component of the RNase MRP complex, are the origin of cartilage-hair hypoplasia. Cartilage-hair hypoplasia is associated with severe dwarfism caused by impaired skeletal development. However, it is not clear why mutations in RMRP RNA lead to skeletal d...

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Publicado en:Sci Rep
Main Authors: Steinbusch, Mandy M. F., Caron, Marjolein M. J., Surtel, Don A. M., Friedrich, Franziska, Lausch, Ekkehart, Pruijn, Ger J. M., Verhesen, Wouter, Schroen, Blanche L. M., van Rhijn, Lodewijk W., Zabel, Bernhard, Welting, Tim J. M.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527100/
https://ncbi.nlm.nih.gov/pubmed/28743979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-06809-5
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