Expression of RMRP RNA is regulated in chondrocyte hypertrophy and determines chondrogenic differentiation

Mutations in the RMRP-gene, encoding the lncRNA component of the RNase MRP complex, are the origin of cartilage-hair hypoplasia. Cartilage-hair hypoplasia is associated with severe dwarfism caused by impaired skeletal development. However, it is not clear why mutations in RMRP RNA lead to skeletal d...

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Udgivet i:Sci Rep
Main Authors: Steinbusch, Mandy M. F., Caron, Marjolein M. J., Surtel, Don A. M., Friedrich, Franziska, Lausch, Ekkehart, Pruijn, Ger J. M., Verhesen, Wouter, Schroen, Blanche L. M., van Rhijn, Lodewijk W., Zabel, Bernhard, Welting, Tim J. M.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527100/
https://ncbi.nlm.nih.gov/pubmed/28743979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-06809-5
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