Lithium Sensitive ORAI1 Expression, Store Operated Ca(2+) Entry and Suicidal Death of Neurons in Chorea-Acanthocytosis

Chorea-Acanthocytosis (ChAc), a neurodegenerative disorder, results from loss-of-function-mutations of chorein-encoding gene VPS13A. In tumour cells chorein up-regulates ORAI1, a Ca(2+)-channel accomplishing store operated Ca(2+)-entry (SOCE) upon stimulation by STIM1. Furthermore SOCE could be up-r...

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Pubblicato in:Sci Rep
Autori principali: Pelzl, Lisann, Hauser, Stefan, Elsir, Bhaeldin, Sukkar, Basma, Sahu, Itishri, Singh, Yogesh, Höflinger, Philip, Bissinger, Rosi, Jemaà, Mohamed, Stournaras, Christos, Schöls, Ludger, Lang, Florian
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5526875/
https://ncbi.nlm.nih.gov/pubmed/28743945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-06451-1
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