Decreased Na(+)/K(+) ATPase Expression and Depolarized Cell Membrane in Neurons Differentiated from Chorea-Acanthocytosis Patients

Loss of function mutations of the chorein-encoding gene VPS13A lead to chorea-acanthocytosis (ChAc), a neurodegenerative disorder with accelerated suicidal neuronal cell death, which could be reversed by lithium. Chorein upregulates the serum and glucocorticoid inducible kinase SGK1. Targets of SGK1...

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Publicado no:Sci Rep
Main Authors: Hosseinzadeh, Zohreh, Hauser, Stefan, Singh, Yogesh, Pelzl, Lisann, Schuster, Stefanie, Sharma, Yamini, Höflinger, Philip, Zacharopoulou, Nefeli, Stournaras, Christos, Rathbun, Daniel L., Zrenner, Eberhart, Schöls, Ludger, Lang, Florian
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7242441/
https://ncbi.nlm.nih.gov/pubmed/32439941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-64845-0
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