Therapeutic targeting of Lyn kinase to treat chorea-acanthocytosis

Chorea-Acanthocytosis (ChAc) is a devastating, little understood, and currently untreatable neurodegenerative disease caused by VPS13A mutations. Based on our recent demonstration that accumulation of activated Lyn tyrosine kinase is a key pathophysiological event in human ChAc cells, we took advant...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Peikert, Kevin, Federti, Enrica, Matte, Alessandro, Constantin, Gabriela, Pietronigro, Enrica Caterina, Fabene, Paolo Francesco, Defilippi, Paola, Turco, Emilia, Del Gallo, Federico, Pucci, Pietro, Amoresano, Angela, Illiano, Anna, Cozzolino, Flora, Monti, Maria, Garello, Francesca, Terreno, Enzo, Alper, Seth Leo, Glaß, Hannes, Pelzl, Lisann, Akgün, Katja, Ziemssen, Tjalf, Ordemann, Rainer, Lang, Florian, Brunati, Anna Maria, Tibaldi, Elena, Andolfo, Immacolata, Iolascon, Achille, Bertini, Giuseppe, Buffelli, Mario, Zancanaro, Carlo, Lorenzetto, Erika, Siciliano, Angela, Bonifacio, Massimiliano, Danek, Adrian, Walker, Ruth Helen, Hermann, Andreas, De Franceschi, Lucia
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8091687/
https://ncbi.nlm.nih.gov/pubmed/33941276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-021-01181-y
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