Therapeutic targeting of Lyn kinase to treat chorea-acanthocytosis

Chorea-Acanthocytosis (ChAc) is a devastating, little understood, and currently untreatable neurodegenerative disease caused by VPS13A mutations. Based on our recent demonstration that accumulation of activated Lyn tyrosine kinase is a key pathophysiological event in human ChAc cells, we took advant...

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Bibliografiset tiedot
Julkaisussa:Acta Neuropathol Commun
Päätekijät: Peikert, Kevin, Federti, Enrica, Matte, Alessandro, Constantin, Gabriela, Pietronigro, Enrica Caterina, Fabene, Paolo Francesco, Defilippi, Paola, Turco, Emilia, Del Gallo, Federico, Pucci, Pietro, Amoresano, Angela, Illiano, Anna, Cozzolino, Flora, Monti, Maria, Garello, Francesca, Terreno, Enzo, Alper, Seth Leo, Glaß, Hannes, Pelzl, Lisann, Akgün, Katja, Ziemssen, Tjalf, Ordemann, Rainer, Lang, Florian, Brunati, Anna Maria, Tibaldi, Elena, Andolfo, Immacolata, Iolascon, Achille, Bertini, Giuseppe, Buffelli, Mario, Zancanaro, Carlo, Lorenzetto, Erika, Siciliano, Angela, Bonifacio, Massimiliano, Danek, Adrian, Walker, Ruth Helen, Hermann, Andreas, De Franceschi, Lucia
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BioMed Central 2021
Aiheet:
Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8091687/
https://ncbi.nlm.nih.gov/pubmed/33941276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-021-01181-y
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