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APE1 Accelerates Turnover of hOGG1 by Preventing Retrograde Binding to the Abasic Site Product
A major product of oxidative DNA damage is 8-oxoguanine. In humans, 8-oxoguanine DNA Glycosylase (hOGG1) facilitates removal of these lesions, producing an abasic (AP) site in the DNA that is subsequently incised by AP-endonuclease 1 (APE1). APE1 stimulates turnover of several glycosylases by accele...
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| Yayımlandı: | Biochemistry |
|---|---|
| Asıl Yazarlar: | , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2017
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5526596/ https://ncbi.nlm.nih.gov/pubmed/28345889 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00017 |
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