Osteoblast-specific expression of the Fibrous Dysplasia (FD) causing mutation, Gsα(R201C) produces a high bone mass phenotype but does not reproduce FD in the mouse

We recently reported the generation and initial characterization of the first direct model of human Fibrous Dysplasia (OMIM #174800), obtained through the constitutive systemic expression of one of the disease causing mutations, Gsα(R201C), in the mouse. To define the specific pathogenetic role(s) o...

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Detalhes bibliográficos
Publicado no:J Bone Miner Res
Main Authors: Remoli, Cristina, Michienzi, Stefano, Sacchetti, Benedetto, Di Consiglio, Alberto, Cersosimo, Stefania, Spica, Emanuela, Robey, Pamela G., Holmbeck, Kenn, Cumano, Ana, Boyde, Alan, Davis, Graham, Saggio, Isabella, Riminucci, Mara, Bianco, Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5526456/
https://ncbi.nlm.nih.gov/pubmed/25487351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.2425
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