Tumor suppressor RecQL5 controls recombination induced by DNA crosslinking agents

RecQ family DNA helicases function in the maintenance of genome stability. Mice deficient in RecQL5, one of five RecQ helicases, show a cancer predisposition phenotype, suggesting that RecQL5 plays a tumor suppressor role. RecQL5 interacts with Rad51, a key factor in homologous recombination (HR), a...

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Detalhes bibliográficos
Publicado no:Biochim Biophys Acta
Main Authors: Hosono, Yoshifumi, Abe, Takuya, Ishiai, Masamichi, Islam, M. Nurul, Arakawa, Hiroshi, Wang, Weidong, Takeda, Shunichi, Ishii, Yutaka, Takata, Minoru, Seki, Masayuki, Enomoto, Takemi
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5525539/
https://ncbi.nlm.nih.gov/pubmed/24418621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2014.01.005
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