miR-155 effectively induces apoptosis in K562 Philadelphia positive cell line through upregulation of p27kip1

[Image: see text] Introduction: Chronic myelogenous leukemia (CML) is a myeloproliferative disorder caused by the Philadelphia chromosome translocation, at (9; 22), which results in BCR-ABL fusion tyrosine kinase oncoprotein. This fusion induces down-regulation of miR-155. Upregulation of miR-155 ca...

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Publicat a:Bioimpacts
Autors principals: Edalati Fathabad, Mahdi, Karimipoor, Morteza, Alizadeh, Shaban, Abdoli, Asghar, Atashi, Amir, Sayadi, Mahtab
Format: Artigo
Idioma:Inglês
Publicat: Tabriz University of Medical Sciences 2017
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Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5524985/
https://ncbi.nlm.nih.gov/pubmed/28752075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15171/bi.2017.14
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