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Programmable base editing of zebrafish genome using a modified CRISPR-Cas9 system
Precise genetic modifications in model animals are essential for biomedical research. Here, we report a programmable “base editing” system to induce precise base conversion with high efficiency in zebrafish. Using cytidine deaminase fused to Cas9 nickase, up to 28% of site-specific single-base mutat...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5524635/ https://ncbi.nlm.nih.gov/pubmed/28740134 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00175-6 |
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