Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation

Hypoxia regulates autophagy and nucleotide-binding oligomerization domain receptor, pyrin domain containing (NLRP)3, two innate immune mechanisms linked by mutual regulation and associated to IBD. Here we show that hypoxia ameliorates inflammation during the development of colitis by modulating auto...

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發表在:Nat Commun
Main Authors: Cosin-Roger, Jesus, Simmen, Simona, Melhem, Hassan, Atrott, Kirstin, Frey-Wagner, Isabelle, Hausmann, Martin, de Vallière, Cheryl, Spalinger, Marianne R., Spielmann, Patrick, Wenger, Roland H., Zeitz, Jonas, Vavricka, Stephan R., Rogler, Gerhard, Ruiz, Pedro A.
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2017
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5524634/
https://ncbi.nlm.nih.gov/pubmed/28740109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00213-3
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