Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation

Hypoxia regulates autophagy and nucleotide-binding oligomerization domain receptor, pyrin domain containing (NLRP)3, two innate immune mechanisms linked by mutual regulation and associated to IBD. Here we show that hypoxia ameliorates inflammation during the development of colitis by modulating auto...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Cosin-Roger, Jesus, Simmen, Simona, Melhem, Hassan, Atrott, Kirstin, Frey-Wagner, Isabelle, Hausmann, Martin, de Vallière, Cheryl, Spalinger, Marianne R., Spielmann, Patrick, Wenger, Roland H., Zeitz, Jonas, Vavricka, Stephan R., Rogler, Gerhard, Ruiz, Pedro A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5524634/
https://ncbi.nlm.nih.gov/pubmed/28740109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00213-3
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