Monocyte Adhesion, Migration, and Extracellular Matrix Breakdown Are Regulated by Integrin αVβ3 in Mycobacterium tuberculosis Infection

In tuberculosis (TB), the innate inflammatory immune response drives tissue destruction, morbidity, and mortality. Monocytes secrete matrix metalloproteinases (MMPs), which have key roles in local tissue destruction and cavitation. We hypothesized that integrin signaling might regulate monocyte MMP...

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Bibliographic Details
Published in:J Immunol
Main Authors: Brilha, Sara, Wysoczanski, Riccardo, Whittington, Ashley M., Friedland, Jon S., Porter, Joanna C.
Format: Artigo
Language:Inglês
Published: AAI 2017
Subjects:
Infectious Disease and Host Response
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5523580/
https://ncbi.nlm.nih.gov/pubmed/28646039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700128
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