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Monocyte Adhesion, Migration, and Extracellular Matrix Breakdown Are Regulated by Integrin αVβ3 in Mycobacterium tuberculosis Infection

In tuberculosis (TB), the innate inflammatory immune response drives tissue destruction, morbidity, and mortality. Monocytes secrete matrix metalloproteinases (MMPs), which have key roles in local tissue destruction and cavitation. We hypothesized that integrin signaling might regulate monocyte MMP...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Brilha, Sara, Wysoczanski, Riccardo, Whittington, Ashley M., Friedland, Jon S., Porter, Joanna C.
Formato: Artigo
Idioma:Inglês
Publicado em: AAI 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5523580/
https://ncbi.nlm.nih.gov/pubmed/28646039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700128
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