Membrane-bound β-catenin degradation is enhanced by ETS2-mediated Siah1 induction in Helicobacter pylori-infected gastric cancer cells

β-catenin has two different cellular functions: intercellular adhesion and transcriptional activity. The E3 ubiquitin ligase Siah1 causes ubiquitin-mediated degradation of the cytosolic β-catenin and therefore, impairs nuclear translocation and oncogenic function of β-catenin. However, the effect of...

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Vydáno v:Oncogenesis
Hlavní autoři: Das, L, Kokate, S B, Dixit, P, Rath, S, Rout, N, Singh, S P, Crowe, S E, Bhattacharyya, A
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5523059/
https://ncbi.nlm.nih.gov/pubmed/28481365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2017.26
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