Doxycycline Attenuates Leptospira-Induced IL-1β by Suppressing NLRP3 Inflammasome Priming

Doxycycline (Dox), a semisynthetic antibiotic, has been reported to exert multiple immunomodulatory effects. Treatment with Dox has a satisfactory curative effect against leptospirosis. In addition to its antibacterial action, we supposed that Dox also modulated immune response in controlling leptos...

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Vydáno v:Front Immunol
Hlavní autoři: Zhang, Wenlong, Xie, Xufeng, Wu, Dianjun, Jin, Xuemin, Liu, Runxia, Hu, Xiaoyu, Fu, Yunhe, Ding, Zhuang, Zhang, Naisheng, Cao, Yongguo
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2017
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5522854/
https://ncbi.nlm.nih.gov/pubmed/28791016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00857
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